{"id":45171,"date":"2023-01-17T02:45:19","date_gmt":"2023-01-17T00:45:19","guid":{"rendered":"https:\/\/umfcluj.ro\/cercetare\/centrul-de-cercetare-genomica\/platforma\/integrare-clinica-a-datelor-omice\/"},"modified":"2024-04-01T01:56:32","modified_gmt":"2024-03-31T22:56:32","slug":"integration-clinique-des-donnees-omiques","status":"publish","type":"crct","link":"https:\/\/umfcluj.ro\/fr\/recherche\/centre-recherche-genomique\/plateforme\/integration-clinique-donnees-omiques\/","title":{"rendered":"INT\u00c9GRATION CLINIQUE DES DONN\u00c9ES OMIQUES"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"45171\" class=\"elementor elementor-45171 elementor-13009\" data-elementor-post-type=\"crct\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f33edf0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f33edf0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1eab6f08\" data-id=\"1eab6f08\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-48c5195a elementor-widget elementor-widget-text-editor\" data-id=\"48c5195a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Disponibilitatea tot mai mare a datelor de expresie genic\u0103 \u0219i biomolecular\u0103 din noile tehnologii de \u00eenalt\u0103 performan\u021b\u0103 \u00eencepe s\u0103 schimbe abordarea tradi\u021bional\u0103 de fenotip a patologiilor intr-o abordare genetic\u0103 sau de date moleculare. Relevan\u021ba clinic\u0103 a subtip\u0103rii moleculare se bazeaz\u0103 pe capacitatea sa de a conecta mecanismele de baz\u0103 ale bolii cu datele clinice \u0219i fenotipice. Profilele moleculare obtinute pot avea utilitate diagnostica, prognostica si predictiva.<\/p><p><strong>Integrarea clinic\u0103 a datelor omice esentiale<\/strong> (genomic\u0103, transcriptomic\u0103, proteomic\u0103, metabolomic\u0103) ofer\u0103 oportunitatea de a ob\u021bine <strong>perspective noi asupra semnaturii molecurare ce caracterizeaza diferite patologii<\/strong>. Date omice precum statusul mutational al unor gene, microRNA, mRNA, expresia proteinelor, metilare ADN pot fi utilizate pentru a studia interac\u021biunile complexe dintre multiplii factori genetici \u0219i de mediu care apar \u00een timpul patogenezei bolilor precum cancerul si alte boli severe. In boli precum cancerul, poten\u021bialul subtip\u0103rii moleculare pentru avansarea cercet\u0103rii, ghidarea tratamentelor personalizate \u0219i furnizarea unei \u00een\u021belegeri clare a prognosticului \u0219i progresiei bolii a fost d\u00e9j\u00e0 demonstrat<\/p><p>La momentul actual este disponibil un patrimoniu public cu date genetice \u0219i omice referitoare la variantele identificate in diverse tipuri si subtipuri tumorale, acestea fiind rezultate din proiecte de secventiere aplicate la scara larga. Suprapunerea datelor omice ob\u021binute \u00een laborator \u0219i compararea lor cu datele de secventiere disponibile din proiectele aplicate la scar\u0103 larg\u0103 poate oferi informa\u021bii diagnostice sau prognostice, precum \u0219i informat\u021bii predictive referitoare la un poten\u021bial r\u0103spuns la un tratament sau o terapie \u021bintit\u0103 \u0219i pot determina eligibilitatea pentru:<\/p><ul><li>Medica\u021bia aprobat\u0103 pentru acel subtip de boal\u0103<\/li><li>Medica\u021bie disponibil\u0103 ca tratament off-label pentru modificarea molecular\u0103 specific\u0103 \u00eentr-un tip de patologie neaprobat<\/li><\/ul><p>O terapie \u021bintit\u0103 disponibil\u0103 \u00een trialuri clinice cu agen\u021bi investiga\u021bionali pe baza unei modific\u0103ri moleculare identificate.<\/p><p>Abord\u0103rile omice actuale permit o caracterizare f\u0103r\u0103 precedent a profilul molecular al probelor analizate, conferind medicinii moderne noi capabilit\u0103\u021bi predictive, preventive, personalizate \u0219i de precizie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80f9f7f elementor-widget elementor-widget-gallery\" data-id=\"80f9f7f\" data-element_type=\"widget\" data-settings=\"{&quot;image_hover_animation&quot;:&quot;grow&quot;,&quot;gallery_layout&quot;:&quot;justified&quot;,&quot;lazyload&quot;:&quot;yes&quot;,&quot;ideal_row_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;ideal_row_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;ideal_row_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;link_to&quot;:&quot;file&quot;,&quot;content_hover_animation&quot;:&quot;fade-in&quot;}\" data-widget_type=\"gallery.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-gallery__container\">\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/cdn.umfcluj.ro\/uploads\/2023\/01\/DSF8397P-1.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"80f9f7f\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzU5NTEsInVybCI6Imh0dHBzOlwvXC9jZG4udW1mY2x1ai5yb1wvdXBsb2Fkc1wvMjAyM1wvMDFcL0RTRjgzOTdQLTEuanBnIiwic2xpZGVzaG93IjoiODBmOWY3ZiJ9\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/cdn.umfcluj.ro\/uploads\/2023\/01\/DSF8397P-1-768x575.jpg\" data-width=\"768\" data-height=\"575\" aria-label=\"\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":35803,"parent":45153,"menu_order":10,"template":"","format":"standard","class_list":["post-45171","crct","type-crct","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INT\u00c9GRATION CLINIQUE DES DONN\u00c9ES OMIQUES - UMF Cluj<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umfcluj.ro\/fr\/recherche\/centre-recherche-genomique\/plateforme\/integration-clinique-donnees-omiques\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INT\u00c9GRATION CLINIQUE DES DONN\u00c9ES OMIQUES - UMF Cluj\" \/>\n<meta property=\"og:description\" content=\"Disponibilitatea tot mai mare a datelor de expresie genic\u0103 \u0219i biomolecular\u0103 din noile tehnologii de \u00eenalt\u0103 performan\u021b\u0103 \u00eencepe s\u0103 schimbe abordarea tradi\u021bional\u0103 de fenotip a patologiilor intr-o abordare genetic\u0103 sau de date moleculare. 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